本研究应用ELISA法测定染尘大鼠血清和支气管肺泡灌洗液(BALF)中纤维粘蛋白(Fn)含量的变化。实验表明,染有致纤维化能力弱的WO_3粉尘,导致上述两种体液内Fn含量与正常对照大鼠无显著性差异,而染有致纤维化能力强的SiO_2粉尘,则在其发病的前一阶段Fn含量高于对照鼠,病灶内Fn沉积亦较多。这提示测定Fn含量可能有助于矽肺的诊断和病情的分析。 In this study, the changes of fibronectin (Fn) levels in sera and bronchoalveolar lavage fluid (BALF) of rats exposed to dust were detected by ELISA. Experiments show that there is a weak fibrinolytic capacity of WO_3 dust, resulting in the above two kinds of body fluids within the Fn content of normal control rats no significant difference, while stained with high fibrosis ability of SiO 2 dust, then the incidence in the previous stage Fn content higher than the control mice, lesions Fn deposition is also more. This suggests that the determination of Fn content may contribute to the diagnosis of silicosis and disease analysis.