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透明质酸酶(Hyaluronidasum Pro Injectione)系自哺乳动物睾丸、微生物、蛇毒等中提取而得,是一种能促使药物扩散和吸收的药剂,国外已大量生产,并收载在不少国家的药典中。国内亦已开始生产。本品为无毒性、不含热原的白色粉末,每毫克活力在300单位以上,溶于水,不溶于丙酮、95%乙醇和乙醚中。其水溶液无色无臭,以5%水解明胶稀释,经灭菌及冷冻干燥后,呈米白色块状。药理作用本品是一种酶或酶的复合物,对粘多糖-透明质酸有水解作用。透明质酸是人体组织基质的主要成分,能限制液体及细胞外物质的扩散,因此透明质酸酶能促使局部储积液或注射液的扩散,使之易于吸收。
Hyaluronidasum Pro Injection is derived from the mammalian testes, microorganisms, snake venom and so on. It is a kind of agent that can promote the diffusion and absorption of drugs. It has been mass-produced in foreign countries and has been included in Pharmacopoeia of many countries in. Domestic production has also started. This product is non-toxic, pyrogen-free white powder, per milligram of vitality in more than 300 units, soluble in water, insoluble in acetone, 95% ethanol and ether. Its aqueous solution is colorless and odorless, diluted with 5% hydrolyzed gelatin, and sterilized and freeze-dried to form an off-white block. Pharmacological effects This product is an enzyme or enzyme complex, the mucopolysaccharide - hyaluronic acid hydrolysis. Hyaluronic acid is the main component of the human tissue matrix, can limit the liquid and extracellular material diffusion, so hyaluronidase can promote the local accumulation of liquid or injection of the proliferation, so that it is easy to absorb.