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白细胞介素－１（ＩＬ－１）及阿片肽作为神经调质参与了神经细胞兴奋性毒性作用．以大鼠大脑皮层神经细胞为研究对象，探讨了ＩＬ－１、阿片肽和ｃ－ｆｏｓ、ｃ－ｊｕｎ表达产物之间的关系．结果表明，ＩＬ－１β能诱导大脑皮层神经细胞ｃ－ｆｏｓ、ｃ－ｊｕｎｍＲＮＡ瞬时短暂表达，１５ｍｉｎ增高，３０ｍｉｎ达高峰，ｃ－ｆｏｓｍＫＮＡ２ｈ回至基线水平，ｃ－ｊｕｎｍＲＮＡ８ｈ回至基线水平；联合应用ｃ－ｆｏｓ、ｃ－ｊｕｎ反义寡核苷酸能部分抑制ＩＬ－１诱导的大脑皮层神经细胞脑啡肽及β－内啡肽分泌增加，呈一定量效关系，相应意义寡核苷酸无抑制作用．提示ＩＬ－１促进大脑皮层神经细胞脑啡肽及β－内啡肽分泌作用部分受Ｆｏｓ和Ｊｕｎ蛋白调控．
Interleukin-1 (IL-1) and opioid peptides are involved in the neuronal excitotoxicity as neuromodulators. The cerebral cortex neurons in rats as the research object, to explore the relationship between IL-1, opioid peptide and c-fos, c-jun expression products. The results showed that IL-1β induced transient transient expression of c-fos and c-jun mRNA in cerebral cortical neurons at 15 min and reached the peak at 30 min, c-fosmKNA2 h returned to baseline and c-jun mRNA returned to baseline at 8 h. Combination of c- fos and c-jun antisense oligonucleotides could partially inhibit IL-1-induced increase of enkephalin and β-endorphin in cerebral cortex neurons, showing a certain dose-effect relationship, the corresponding sense of inhibition of oligodeoxynucleotides . It is suggested that IL-1 promotes the secretion of enkephalin and β-endorphin in neurons of the cerebral cortex in part by Fos and Jun proteins.