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目的探讨白细胞介素-6(interleukin-6,IL-6)基因174G/C多态性与缺血性脑卒中(ischemic stroke,IS)风险的相关性。方法计算机检索CBM、CNKI、PubMed、MEDLINE和EMbase数据库,收集从建库至2011年8月间关于IL-6基因174G/C多态性与IS风险相关性的病例对照研究,由两名研究者独立进行资料提取、质量评价并交叉核对后,采用RevMan 5.1.2和Stata 11.0软件对符合标准的文献进行Meta分析。结果共纳入12个研究,2537例患者和2767例对照。各遗传模型Meta分析结果显示:IL-6基因174G/C多态性与IS风险的相关性无统计学意义[共显性遗传模型:G/C vs. G/G:OR=0.98,95%CI(0.78,1.24);C/C vs. G/G:OR=0.75,95%CI(0.38,1.50);显性遗传模型:OR=0.93,95%CI(0.68,1.28);隐性遗传模型:OR=0.80,95%CI(0.45,1.42)]。基于人种的亚组分析结果显示两者相关性无统计学意义,而基于对照来源的亚组分析结果显示,对照人群为医院来源的亚组中IL-6基因174G/C多态性是IS的保护因素[共显性遗传模型:G/C vs. G/G:OR=0.56,95%CI(0.40,0.79);C/C vs. G/G:OR=0.17,95%CI(0.11,0.27);显性遗传模型:OR=0.40,95%CI(0.29,0.55);隐性遗传模型:OR=0.24,95%CI(0.16,0.37)]。结论基于目前研究结果显示,IL-6基因174G/C多态性与IS风险无明显相关性。受纳入研究质量和数量限制,上述结论尚待开展更多高质量的前瞻性研究进一步验证。
Objective To investigate the association between the 174G / C polymorphism of interleukin-6 (IL-6) gene and the risk of ischemic stroke (IS). Methods The CBM, CNKI, PubMed, MEDLINE and EMbase databases were retrieved by computer. A case-control study was conducted on the association between the 174G / C polymorphism of IL-6 gene and risk of IS in our database from August 2004 to August 2011. Two case- After independent data extraction, quality assessment and cross-checking, Meta-analysis was performed on standards-compliant literature using RevMan 5.1.2 and Stata 11.0 software. Results A total of 12 studies, 2537 patients and 2767 controls were included. Meta-analysis showed that there was no significant difference between the 174G / C polymorphism of IL-6 gene and the risk of IS [co-dominant genetic model: G / C vs. G / G: OR = 0.98, 95% (0.78,1.24); C / C vs. G / G: OR = 0.75,95% CI (0.38,1.50); Dominant genetic model: OR = 0.93,95% CI Model: OR = 0.80, 95% CI (0.45, 1.42)]. The ethnic-based subgroup analysis showed no significant correlation between the two, whereas subgroup analyzes based on control sources showed that the 174 G / C polymorphism of the IL-6 gene in the subgroup of control-hospitalized populations was IS Of the protective factors [co-dominant genetic model: C / C vs. G / G: OR = 0.17, 95% CI , 0.27); Dominant genetic model: OR = 0.40, 95% CI (0.29, 0.55); Implicit genetic model: OR = 0.24, 95% CI (0.16,0.37)]. Conclusions Based on the results of the present study, there is no significant correlation between the 174G / C polymorphism of IL-6 gene and the risk of IS. Due to the quality and quantity limitations of the studies, the above conclusions have yet to be further validated by more high-quality prospective studies.