α-干扰素(IFN-α)和白细胞介素-2(IL-2)都是免疫系统中重要的细胞因子,但它们在神经系统中也发挥着重要作用.已有报道表明,IL-2有中枢和外周的镇痛作用,IFN-α有中枢镇痛作用.研究发现,IFN-α也具有外周镇痛作用,且该作用和IL-2一样可被纳络酮阻断.进一步研究显示,IFN-α的外周镇痛作用可被抗IL-2的单抗反转.体外实验表明,IFN-α能剂量依赖性地诱导IL-2的产生.因此,IFN-α的外周镇痛作用是由IL-2介导的. Alpha-interferon (IFN-α) and interleukin-2 (IL-2) are important cytokines in the immune system, but they also play important roles in the nervous system. It has been reported that IL-2 Central and peripheral analgesia, IFN-α central analgesic effect.Studies found that, IFN-α also has peripheral analgesic effect, and the role and IL-2 can be blocked by naloxone further studies have shown , The peripheral analgesic effect of IFN-α can be reversed by anti-IL-2 monoclonal antibody.Experimental results show that IFN-α can induce IL-2 production in a dose-dependent manner.Therefore, the peripheral analgesic effect of IFN-α Is mediated by IL-2.