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纤维连接蛋白(fibronectin FN)分为血浆中 FN 和组织中 FN,血浆中的 FN 有调理作用,而组织中 FN 主要是结构成分。在创伤应激时,血浆中 FN 因种属不同而有差异。一般认为人体在创伤后早期因机体消耗大于生成导致血浆 FN 明显下降,致使 RES 吞噬异物能力下降,引起一系列病理生理变化。而在小鼠等啮齿动物因有较强的合成 FN 的能力,在创伤时不一定下降,甚有明显升高。在创口愈合中 FN 起主导作用,随着 FN 受体的发现,对 FN 在创口愈合中的作用有了进一步认识,FN 与创口中成纤维细胞、基底细胞等的 FN 受体结合,使伤口收缩,促进伤口愈合。
Fibronectin (FN) is divided into FN in plasma and FN in tissue. FN in plasma has a regulatory effect, whereas FN in tissue is mainly a structural component. In traumatic stress, plasma FN varies by species. Generally believed that the human body in the early post-traumatic injury due to consumption of more than the formation of plasma FN decreased significantly, resulting in ability of RES phagocytosis foreign body decreased, causing a series of pathophysiological changes. In mice and other rodents because of the strong ability to synthesize FN, not necessarily decreased in the trauma, and even significantly increased. FN plays a leading role in the healing of wounds. With the discovery of FN receptors, the effect of FN on wound healing has been further recognized. FN binds FN receptors such as fibroblasts and basal cells in the wound to shrink the wound , Promote wound healing.