该项研究长期目的是为了生产菌苗、抗原和诊断试剂,研制出遗传性状发生改变的无毒布氏菌株。我们最初研究是针对确定在布氏菌属范围内发生遗传变异的机制。本文报告是利用最近分离的两群布氏菌噬菌体研究在不同布氏菌间遗传物质的转移中噬菌体的可能作用。“2M”噬菌体是从一些非典型牛种布氏菌2生物型菌株中分离出来,这些菌株是从不 The long-term goal of the study was to produce bacterins, antigens and diagnostic reagents, and to develop non-toxic brucella strains with altered genetic traits. Our initial study was aimed at determining the mechanism by which genetic variation occurs within the genus Brucella. This paper reports the possible role of phages in the transfer of genetic material between different Brucella strains using two recently isolated groups of B. bacteriophages. The “2M” phages are isolated from some atypical B. brevis 2 biotype strains that never