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为了解基质降解在慢性肝病中的作用,对慢性肝炎、肝硬化患者的血清Ⅳ型胶原降解酶活性进行了研究.结果表明:慢性肝炎、肝硬化患者的血清Ⅳ型胶原降解酶活性均显著高于正常对照组;慢性肝炎患者酶活性较肝硬化患者亦显著为高.血清Ⅳ型胶原降解酶活性与PⅢP、Laminin间均呈显著负相关.上述结果提示.Ⅳ型胶原降解酶可能参与了慢性肝病的病理发生;随着慢性肝病的进展,酶活性逐渐下降.
In order to understand the role of matrix degradation in chronic liver disease, the serum type Ⅳ collagenolytic enzyme activity in patients with chronic hepatitis and cirrhosis was studied.The results showed that the serum type Ⅳ collagen degrading enzyme activity in patients with chronic hepatitis and cirrhosis was significantly higher In normal control group, the activity of enzyme in patients with chronic hepatitis was significantly higher than those in patients with liver cirrhosis.Serum collagenase Ⅳ activity was negatively correlated with PⅢP and Laminin.The above results suggest that type Ⅳ collagen degrading enzyme may be involved in chronic Pathogenesis of liver disease; with the progress of chronic liver disease, enzyme activity decreased.