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硒(Se)是动物也是人类的必需的膳食组份,如过量则有毒性。尽管大多数报道称慢性摄食有机硒可引起硒中毒,但同时报道了亚硒酸钠也有毒性。由于硒毒理学对动物和人类有重要意义,我们进行了许多研究,以阐明硒毒性对大鼠锌、铁和铜在组织中分布的影响。我们发现硒中毒的大鼠的肝、肾和心的铜浓度显著地高于非中毒的对照组。
Selenium (Se) is an essential dietary component for animals and humans and is toxic if it is in excess. Although most reports reported that chronic ingestion of organic selenium can cause selenium poisoning, it is also reported that sodium selenite is also toxic. As selenium toxicology is important in animals and humans, we conducted many studies to elucidate the effects of selenium toxicity on the distribution of zinc, iron and copper in rats. We found that selenium poisoned rats had significantly higher liver, kidney and heart copper concentrations than non-toxic controls.