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为探讨分流与断流对门脉高压时胃粘膜的影响，本实验采用ＣＣＬ４皮下注射诱导制作肝硬变门脉高压大鼠模型，模仿临床方法施行肠腔分流与联合断流术，以假手术作对照同步观察两类手术对肝硬变门脉高压大鼠胃粘膜多项功能与形态学指标的影响。结果显示：两类手术在实验观测时期内均有显著降低门静脉压作用，降压幅度以分流术为大；同对照组相比，分流组胃粘膜血流量、胃粘膜电位差显著增加，胃粘膜下层厚度、血管相对横截面积及胃粘膜病变指数明显降低，提示分流术后胃粘膜血运循环得到改善，胃粘膜屏障功能得以恢复，胃粘膜充血水肿减轻及胃粘膜病变减轻，而断流组除粘膜下层厚度及血管相对横截面积有轻度降低外，上述其他指标均呈相反结果。
In order to investigate the effect of shunt and flow-off on gastric mucosa in portal hypertension, CCL4 subcutaneous injection was used to induce rat model of portal hypertension caused by cirrhosis, and to imitate the clinical method to perform shunt of intestine and combined disconnection, Simultaneous observation of two types of surgery for the control of liver cirrhosis with portal hypertension in rats a number of functions and morphological indicators. The results showed that both types of surgery significantly reduced the portal venous pressure during the experimental period and the rate of decrease was shunt; the gastric mucosal blood flow and gastric mucosal potential were significantly increased in the shunt group compared with those in the control group. Gastric mucosa Lower layer thickness, relative cross-sectional area of blood vessels and gastric mucosal lesion index decreased significantly, suggesting that gastric bypass blood circulation improved, gastric mucosal barrier function was restored, gastric mucosal edema lesion and gastric mucosal lesions reduced, In addition to the submucosal thickness and relative cross-sectional area of blood vessels decreased slightly, the other indicators were the opposite result.