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目的研究拉米夫定与原儿茶酸联合使用对各自在大鼠体内药动学的影响。方法将wistar大鼠随机分为拉米夫定组(100 mg·kg-1),原儿茶酸组(100 mg·kg-1),拉米夫定+原儿茶酸组(100+100 mg·kg-1),每组6只,单次灌胃给药后,于不同时间点采集血样。用HPLC测定大鼠血药中拉米夫定与原儿茶酸的浓度,血药浓度-时间数据采用3P97软件进行药动学分析。结果与两种药物单独使用相比,联用后拉米夫定的V/F显著减小,AUC0-t显著增大,t1/2ka极显著增大,tpeak显著增大,CL/F极显著减小;原儿茶酸的t1/2β显著增大,t1/2ka、tpeak极显著增大。结论两药联用使用后,存在明显的药动学相互作用。
Objective To study the effects of lamivudine combined with protocatechuic acid on their pharmacokinetics in rats. Methods Wistar rats were randomly divided into 5 groups: lamivudine group (100 mg · kg -1), protocatechuic acid group (100 mg · kg -1), lamivudine + protocatechuic acid group mg · kg-1), 6 in each group. After a single gavage, blood samples were taken at different time points. The plasma concentrations of lamivudine and protocatechuic acid in rat plasma were determined by HPLC. Pharmacokinetic analysis was performed using 3P97 software. Results Compared with the two drugs alone, V / F of lamivudine significantly decreased, AUC0-t increased significantly, t1 / 2ka increased significantly, tpeak increased significantly, CL / F significantly increased Decreased; protocatechuic acid t1 / 2β significantly increased, t1 / 2ka, tpeak significantly increased. Conclusion The combination of two drugs, there is a clear pharmacokinetic interaction.