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目的观察健念防风汤联合阿司匹林、低分子肝素钙治疗短暂性脑缺血发作的临床疗效。方法将116例短暂性脑缺血发作患者随机分为治疗组(60例)和对照组(56例)。两组均予阿司匹林片、低分子肝素钙注射液治疗,治疗组同时加用中药健念防风汤。两组疗程均为14天,于用药3天时观察近期病情控制情况;疗程结束后随访3个月,观察远期临床疗效及脑梗死发病情况。结果治疗组、对照组近期病情控制率分别为73.3%、57.1%,治疗组优于对照组(P<0.05)。治疗组、对照组远期临床总有效率分别为86.7%、73.2%,治疗组远期临床疗效优于对照组(P<0.05)。治疗组、对照组随访3个月时的脑梗死发生率分别为10.0%、25.0%,治疗组低于对照组(P<0.05)。结论健念防风汤联合阿司匹林片、低分子肝素钙注射液治疗短暂性脑缺血发作疗效满意。
Objective To observe the clinical efficacy of Jian-nian Fangfeng Decoction combined with aspirin and low-molecular-weight heparin in the treatment of transient ischemic attack. Methods 116 patients with transient ischemic attack were randomly divided into treatment group (60 cases) and control group (56 cases). Both groups were given aspirin tablets, low molecular weight heparin calcium injection, the treatment group also added traditional Chinese medicine Jianfeng soup. The two courses of treatment were 14 days, observed in the recent 3 days medication condition control; after the end of treatment for 3 months, observe the long-term clinical efficacy and incidence of cerebral infarction. Results The disease control rates in the treatment group and the control group were 73.3% and 57.1% respectively, which were better than those in the control group (P <0.05). The long-term clinical total effective rates of the treatment group and the control group were 86.7% and 73.2%, respectively. The long-term clinical efficacy of the treatment group was better than that of the control group (P <0.05). The incidence of cerebral infarction in the treatment group and the control group at 3 months follow-up was 10.0% and 25.0% respectively, which was lower in the treatment group than in the control group (P <0.05). Conclusion Jian-nian Fangfeng Decoction combined with aspirin tablets, low-molecular-weight heparin injection in the treatment of transient ischemic attacks with satisfactory results.