一、激素类药物可的松类激素药物长期应用，可抑制骨髓生长，拮抗维生素D的作用，使钙的吸收减少而排出增加，可致骨质疏松、骨软化症发生。二、抗生素类药物抗生素类药中数利福平对骨软化作用明显，它在抗结核治疗中需用较长时间，由于它使维生素D代谢增加，体内含量减少，故 First, the hormone drugs cortisone hormone long-term use of drugs can inhibit bone marrow growth, antagonize the role of vitamin D, calcium absorption and reduce the discharge increased, can cause osteoporosis, osteomalacia occurs. Second, antibiotics Antibiotic drugs in the number of rifampicin obvious effect on bone softening, it takes a long time in anti-TB treatment, because it increases vitamin D metabolism, reduce the body content, so