目的　观察不同月龄小鼠骨有机质和矿物质的变化 ,探讨小鼠骨质组成成分随月龄增长而变化的规律 ,为用小鼠建立骨质疏松模型提供实验数据。方法　分别取 1～ 5月龄小鼠 ,按不同月龄分成 5组 ,测体重 ,取股骨分别测定骨干重、骨横短径 ,骨矿物质钙、磷、镁、锌、锰、硫及骨有机质羟脯氨酸 (B HOP) ,进行组间比较。结果　不同月龄小鼠骨干重 ,骨横短径 ,骨有机质的主要成分骨羟脯氨酸 (HOP) ,骨矿物质随着月龄增加有不同程度的增长 ;但骨微量元素的变化不大 ,骨HOP及骨钙的增加与骨干重的比值密切相关。结论　不同月龄小鼠骨物理指标、骨有机质和矿物质指标均随月龄的增大呈不同程度的改变 ,骨微量元素改变不大 OBJECTIVE: To observe the changes of bone organic matter and minerals in mice of different ages, and to explore the regularity of bone components in mice with the increase of age. The experimental data are provided for the establishment of osteoporosis model in mice. Methods The mice of 1 to 5 months old were divided into 5 groups at different ages to measure the body weight, take the femur to measure the weight of the bone, the transverse diameter of the bone, the calcium, phosphorus, magnesium, zinc, manganese, sulfur and bone Organic hydroxyproline (B HOP), for comparison between groups. Results The bone weight, short transverse bone length and the main components of bone organic matter (HOP) and bone mineral in different age mice increased with the increase of age, but little change in trace elements , Bone HOP and bone calcium increased with the ratio of bone weight is closely related. Conclusion The bone mineral index, bone organic matter and mineral index of mice of different ages all changed to varying degrees with the increase of age, while the trace elements of bone did not change much