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由缺氧性血管收缩引起的肺动脉高压被认为是高原性肺水肿的重要病理因素。作者发现硝苯啶可以降肺低动脉压、改善患者的活动能力、气体交换及肺水肿的X线表现。因而,假设预防性的应用硝苯啶可以预防肺水肿的复发。方法 21例登山运动员(女性1例,男性20例),均有经X线证实的高原性肺水肿,随机分为治疗组(10例)及对照组(11例),在22小时内从平原迅速登到4559米处,在高原停留三天。从登山开始治疗组每人每8小时口
Pulmonary hypertension caused by hypoxic vasoconstriction is considered as an important pathological factor for high altitude pulmonary edema. The authors found that nifedipine can reduce pulmonary arterial pressure, improve patient mobility, gas exchange and pulmonary edema of the X-ray findings. Thus, it is hypothesized that prophylactic use of nifedipine may prevent the recurrence of pulmonary edema. Methods Twenty-one mountain climbers (1 female and 20 males) were enrolled in this study. All of them had X-ray confirmed pulmonary edema. They were randomly divided into treatment group (n = 10) and control group (n = 11) Quickly climbed to 4559 meters, stay in the plateau for three days. Beginning from mountaineering treatment group every 8 hours mouth