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目的:分析前哨淋巴结活检(SLNB)在早期乳腺癌治疗中的应用价值。方法:2007-07-01-2011-05-27郑州大学第一附属医院乳腺外二科行SLNB 74例,选择其中61例最终行SLNB替代腋淋巴结清除(ALND)的病例资料为研究组,同期行ALND后病理检查确诊淋巴结≤1并有完整随访资料的83例临床T1～2N0～1M0期乳腺癌患者作为对照组。对比分析两组间术后并发症的差异。结果:74例行乳腺癌SLNB病例中,SLNB检出率为94.59%(70/74),假阴性率为2.86%(2/70);SLNB组的术后并发症患侧上肢水肿、疼痛和感觉障碍分别占8.2%、19.7%和13.1%,低于ALND组的25.3%、49.4%和40.9%,差异有统计学意义,P<0.05;SLNB组患侧与健侧上臂臂围差为(0.27±0.32)cm,ALND组为(0.79±0.04)cm,差异有统计学意义,P<0.05。结论:SLNB技术简便、安全、可靠、并发症少,对有SLNB适应证的患者,应首选SLNB。
Objective: To analyze the value of sentinel lymph node biopsy (SLNB) in the treatment of early breast cancer. Methods: Totally 74 cases of SLNB from the Second Affiliated Hospital of Zhengzhou University were enrolled in this study. The data of 61 cases who underwent SLNB instead of axillary lymph node dissection (ALND) 83 patients with clinical stage T1 ~ 2N0 ~ 1M0 breast cancer diagnosed lymph node ≤1 and complete follow-up data after ALND were taken as control group. Comparisons of postoperative complications between the two groups were made. Results: The detection rate of SLNB was 94.59% (70/74) in 74 breast cancer patients with SLNB, and the false negative rate was 2.86% (2/70). The postoperative complications of SLNB group included upper limb edema, pain and The sensory disturbances accounted for 8.2%, 19.7% and 13.1% respectively, which were lower than 25.3%, 49.4% and 40.9% in ALND group (P <0.05) 0.27 ± 0.32) cm, ALND group was (0.79 ± 0.04) cm, the difference was statistically significant, P <0.05. Conclusion: The technique of SLNB is simple, safe and reliable with few complications. SLNB should be the first choice for patients with SLNB indications.