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目的 :通过临床病例资料回顾性分析探讨氯氮平临床应用中的常见并发症,并总结其相应的预防与处理措施,以提高今后临床用药的安全性。方法 :以我院精神科住院部于2014年1月至2014年12月期间收治的177例给予氯氮平治疗的精神疾病患者作为本组研究的观察对象,观察患者各类并发症的发生情况,并对相应预防处理措施进行总结分析。结果:本组177例精神疾病患者中,共发生并发症51例,并发症发生率为28.81%;其中心脏副作用45例(25.42%,其中心动过速22例,QT间期延长15例,尖端扭转性室速5例,心律失常3例),勃起功能异常4例(2.26%),中毒急性肺水肿2例(1.13%);所有并发症病例均经相应处理后症状得到缓解,未发生猝死病例。结论 :在抗精神药物临床应用中,心脏副作用与处理可以有效缓解临床症状,提高治疗效果与用药安全。
OBJECTIVE: To retrospectively analyze the common complications of clinical application of clozapine and summarize the corresponding prevention and treatment measures through clinical data to improve the safety of clinical medication in the future. Methods: A total of 177 patients with mental illness who were treated with clozapine in our Department of Psychiatry from January 2014 to December 2014 were enrolled in this study. Observe the occurrence of various complications , And the corresponding preventive measures to conduct a summary analysis. Results: Among the 177 patients with mental illness, 51 patients had complication and the complication rate was 28.81%. There were 45 patients with heart failure (25.42%), including 22 cases of tachycardia, 15 cases of QT prolongation, 5 cases of reversal ventricular tachycardia, 3 cases of arrhythmia), erectile dysfunction in 4 cases (2.26%) and acute pulmonary edema in 2 cases (1.13%). All the complications were relieved without any sudden death Case. Conclusion: In the clinical application of antipsychotic drugs, heart side effects and treatment can effectively relieve clinical symptoms and improve the therapeutic effect and medication safety.