近年来,口服降血糖剂磺脲类药物中的甲磺吡脲作为可望防止糖尿病性视网膜病变发展的药剂而引人注目。作者通过给予目前应用最广泛的口服降糖药——优降糖,使患者血糖处于稳定控制状态后,改为甲磺吡脲,以比较两者的临床降血糖作用。研究对象为20例Ⅱ型糖尿病门诊患者,给予优降糖2.5～5.0mg,使血糖处于控制状态达4个月以上。患者年龄43～81(平均64)岁,病程1～20(平均9)年, In recent years, methamphetamine in sulfonylureas, an oral hypoglycemic agent, has drawn attention as an agent that is expected to prevent the development of diabetic retinopathy. By giving the most widely used oral hypoglycemic agent - glyburide, the patient’s blood glucose in a stable state of control, to metsulfuron-methyl, in order to compare the clinical hypoglycemic effect of both. The subjects were 20 cases of type 2 diabetes outpatients, given glyburide 2.5 ~ 5.0mg, blood glucose in a controlled state for more than 4 months. Patients aged 43 to 81 (average 64) years of age, duration of 1 to 20 (average 9) years,