本文报道用酶联免疫吸附试验检测长爪沙鼠及BALB/cCR小鼠经不同途径感染周期型马来丝虫3期幼虫、微丝蚴和成虫后,血清特异性IgM、IgG抗体的变化规律,以及抗体水平变化与感染虫期的关系。实验鼠在感染后IgM出现及达到高峰的时间较IgG为早,IgM和IgG在达到高峰后,在较长时间内保特一定水平,这可能是寄生蠕虫感染的共同免疫特征。小鼠产生的抗体水平较沙鼠高。 This article reports the enzyme-linked immunosorbent assay (ELISA) was used to detect the changes of serum specific IgM and IgG antibodies in the gerbils of third instar larvae, microfilariae and adult worms of the gerbils of gerbil and BALB / cCR mice infected by different pathways , As well as the relationship between the changes of antibody level and infection stage. The onset and peak time of IgM in experimental mice was earlier than that of IgG. IgM and IgG reached a certain level after a certain period of time, which may be the common immunological feature of parasitic worm infection. Mice produced higher levels of antibodies than gerbils.