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目的：评价依沙吖啶用作中期妊娠引产中米非司酮的作用。方法：按双盲对照法，用药组３０例，年龄２５．０±ｓ２．０ａ，孕周２０±３ｗｋ，给米非司酮２００ｍｇ，ｐｏ，ｑｄ，对照组３０例，年龄２５±３ａ，孕周２０±４ｗｋ用维生素Ｃ（安慰剂），２组所用药品外形相同，皆ｑｄ×２次，２组用药后立即羊膜腔注射依沙吖啶０．１ｇ待产。结果：用药组引产时间４３±１３ｈ明显短于对照组５８±１４ｈ，Ｐ＜０．０１；２组孕妇２ｄ内引产成功率分别为８３％和６０％，Ｐ＜０．０５；未见用药组产后出血量增加，Ｐ＞０．０５，不良反应有恶心，阴道出血，仅１例有严重腹痛。结论：米非司酮可以明显缩短依沙吖啶的中期妊娠引产时间。
Objective: To evaluate the role of ethacridine in the induction of mifepristone in mid-term pregnancy. Methods: According to the double-blind control method, 30 patients (age 25.0 ± s2.0a, gestational weeks 20 ± 3wk) were treated with mifepristone 200mg, po, qd, control group 30 cases, age 25 ± 3a, Week 20 ± 4wk with vitamin C (placebo), two groups of drugs used the same shape, all qd × 2, 2 groups immediately after administration of amniotic fluid injection of ethacridine 0.1g to be produced. Results: The induction time of 43 ± 13h was significantly shorter in the treatment group than that in the control group (58 ± 14h, P <0.01). The success rates of induction of labor in the two groups were 83% and 60%, respectively, within 2 days Postpartum hemorrhage increased, P> 0.05, adverse reactions were nausea, vaginal bleeding, only 1 case had severe abdominal pain. Conclusion: Mifepristone can obviously shorten the induction of labor in the second trimester of Ethacridine.