论文部分内容阅读
目的：探讨Ｐ２１ 基因在喉癌分化中的意义。方法：采用ＬＳＡＢ免疫组化染色法对４３ 例喉癌手术标本的Ｐ２１蛋白进行标记。结果：随癌分化程度下降Ｐ２１蛋白阳性表达率呈下降趋势，低分化者阳性率显著低于中等分化及高分化者（Ｐ＜ ０．０５）。结论：Ｐ２１ 蛋白表达的变化与癌的分化程度密切相关，是癌恶性程度的重要决定指标
Objective: To investigate the significance of P21 gene in the differentiation of laryngeal carcinoma. Methods: P21 protein was detected in 43 cases of laryngeal cancer by LSAB immunohistochemical staining. Results: The positive rate of P21 protein decreased with the degree of cancer differentiation, and the positive rate of poorly differentiated cells was significantly lower than that of moderately differentiated and well differentiated ones (P <0.05). Conclusion: The change of P21 protein expression is closely related to the degree of differentiation of cancer and is an important determinant of malignancy