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为了进一步解决喘通的前体药物——双羟荼酸喘通在体内的长效作用,制成了肠溶颗粒装入硬胶囊,及将肠溶颗粒压成片剂两种剂型。用体外溶出试验与临床平喘时间相结合得出体外溶出最低浓度,并以此比较两种制剂的缓释效果。肠溶颗粒压成片剂为比较理想的长效喘通制剂。它能较恒定地缓释药物,体外溶出最低浓度达10小时以上。并试用于临床,初步取得了予期的副作用小、平喘时间达12小时的良好效果。
In order to further solve the long-acting effect of blebetic acid, a precursor drug for asthma, enteric capsules are prepared into hard capsules and enteric granules are compressed into tablets in two dosage forms. In vitro dissolution test and clinical asthma time combined to obtain the lowest concentration in vitro dissolution, and in order to compare the sustained-release effect of the two preparations. Enteric-coated granules into tablets is the ideal long-acting asthmatic preparations. It can be more sustained release of drugs, in vitro dissolution of the minimum concentration of 10 hours or more. And trial in clinical, initially made the expected side effects, anti-asthma time up to 12 hours of good results.