随着抗菌药物的不断发展,同一药物的不同剂型:片剂、胶囊、糖浆、干糖粉等也随之增加。临床实践证明,同一药物的不同剂型常可影响临床疗效。药物的晶型、颗粒的大小、压片时受热程度,表面活性剂的应用与否、赋形剂的配方,制作工艺等也属主要的影响因素。同一药物不同剂型虽在化学质量检验上可以没有差别,但在药效上却可能有很大不同。因而在70年代发展了生物利用 With the continuous development of antibacterial drugs, different dosage forms of the same drug: tablets, capsules, syrups, dry powdered sugar, etc. also increase. Clinical practice shows that different dosage forms of the same drug can often affect clinical efficacy. Drug crystal form, the size of the particles, the degree of heating tabletting, the surfactant application or not, the formulation of excipients, the production process is also a major influencing factor. Although different dosage forms of the same drug may have no difference in chemical quality inspection, the efficacy may vary greatly. As a result, bioavailability was developed in the 1970s