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的 旨在探讨血清肌钙蛋白I(TnI)水平变化与冠心病患者冠状动脉病变 (病变表面形态、病变范围及程度 )的关系。方法 根据冠状动脉造影结果对 12 4例观察对象进行分组。 (1)按照冠状动脉病变表面形态特征分为 :简单病变组 5 6例 ,复杂病变组 6 8例。 (2 )按照冠状动脉病变范围分为 :单支病变组 5 3例 ,多支病变组 71例。 (3)按照冠状动脉病变程度 (Gensini积分法 )分为 :轻度病变组 5 0例 ,重度病变组 74例。另设正常对照组 2 2例。用酶联免疫吸附测定法 (ELISA)检测血清TnI含量 ,比较不同组间TnI含量的差别。结果 血清TnI含量 :复杂病变组 [(0 80 5± 1 2 6 2 ) μg/L]明显高于简单病变组 [(0 32 3± 0 311) μg/L]及正常对照组 [(0 12 5± 0 12 1) μg/L],差异有显著性 (P <0 0 1)。多支病变组高于单支病变组 ,重度病变组高于轻度病变组 ,差异均有显著性 (P <0 0 5 )。结论 血清TnI水平与冠心病患者冠状动脉病变稳定性、范围、程度相关 ,其水平的增高有助于冠状动脉不稳定病变的识别。
The aim of this study was to investigate the relationship between changes of serum troponin I (TnI) levels and coronary artery lesions (surface morphology, extent and extent of lesions) in patients with coronary heart disease. Methods According to the result of coronary angiography, 124 cases were divided into groups. (1) According to the morphological features of coronary artery lesions, there were 56 simple lesions and 68 complicated lesions. (2) According to the range of coronary artery disease, there were 53 cases in single vessel disease group and 71 cases in multiple vessel disease group. (3) According to the severity of coronary artery disease (Gensini integral method), the patients were divided into mild lesion group (50 cases) and severe lesion group (74 cases). Another set of normal control group 22 cases. Serum TnI levels were detected by enzyme-linked immunosorbent assay (ELISA), and the differences of TnI levels among different groups were compared. Results Serum TnI levels were significantly higher in patients with complex lesions (0 80 5 ± 1 2 6 2 μg / L) than those in patients with simple lesions (0 32 3 ± 0 311 μg / L) and in controls 5 ± 0 12 1) μg / L], the difference was significant (P <0.01). The multi-vessel lesion group was higher than the single vessel lesion group, the severe lesion group was higher than the mild lesion group, the difference was significant (P <0 05). Conclusions Serum TnI level is correlated with the stability, range and degree of coronary artery disease in patients with coronary heart disease. The increased level of TnI contributes to the identification of unstable coronary artery disease.