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目的 :研究氨茶碱与尼群地平合用时是否需调整其剂量。方法 :建立以 β 羟基茶碱为内标而检测血清茶碱的高效液相色谱法 ,8只大白兔于第 1、7天单次静注氨茶碱 12 .5mg·kg-1,第 2～ 7天灌服尼群地平 10mg·kg-1,bid。用氨茶碱后各时间点静脉采血 ,测定茶碱血药浓度 ,用 3P87药动学软件计算参数 ,用t检验进行统计。结果 :单用氨茶碱与合用尼群地平的药时曲线呈二室开放模型 ,T1/2α分别为 (1.9± 0 .7) ,(1.4± 0 .8)h ;T1/2 β分别为 (14.4± 8.3) ,(17.8± 2 0 .0 )h ;MRT分别为 (6 .4±1.0 ) ,(6 .2± 0 .6 )h ;Cl分别为 (6 8.1± 15 .6 )× 10 -3 ,(77.9± 16 .6 )× 10 -3 L·kg-1·h-1;AUC分别为 (16 1.8± 2 2 .2 ) ,(15 2 .5± 35 .1)mg·L-1·h。结论 :所有药动学参数经t检验 ,P >0 .0 5 ,说明尼群地平对茶碱的药动学无影响。
Objective: To study whether aminophylline and nitrendipine should be adjusted in dosage. Methods: A high performance liquid chromatography (HPLC) method was established for the determination of serum theophylline with β-hydroxy theophylline as the internal standard. A total of 8 rabbits were given intravenous aminophylline 12.5 mg · kg-1 on day 1, day 7, ~ 7 days drip nitrendipine 10mg · kg-1, bid. After taking aminophylline intravenous blood at various time points, determination of theophylline plasma concentration, with 3P87 pharmacokinetic software to calculate the parameters, using t test statistics. Results: The curves of aminophylline and nitrendipine alone showed a two-compartment open model with T1 / 2α of (1.9 ± 0.7) and (1.4 ± 0.8) h respectively. T1 / 2 β were (14.4 ± 8.3) and (17.8 ± 20.0) h respectively; MRT was (6.4 ± 1.0) and (6.2 ± 0.6) h respectively; Cl was (6 8.1 ± 15.6) × 10 (77.9 ± 16.6) × 10-3 L · kg-1 · h-1, respectively; AUC were (16 1.8 ± 2.2 2), (15 2.5 ± 35.1) mg · L-1 · h. Conclusion: All pharmacokinetic parameters by t test, P> 0.05, indicating that nitrendipine pharmacokinetics of theophylline had no effect.