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本文介绍了脾切除治疗特发性骨髓外化生(AMM)的疗效评价。从1960～1977年作者所在单位共收治AMM385例,其中50例进行了脾切除术,男性24例,女性26例。手术时的平均年龄为57岁(36～79岁)。手术适应症有:(1)疼痛性脾肿大;(2)难治性血小板减少;(3)难治性溶血性贫血;(4)伴有门脉高压。疗效:26例疼痛性脾肿大者,术后25例疼痛消失,放疗或烷化剂治疗虽可使66%患者脾脏缩小,疼痛减轻,但只能缓解3～4个月,远不如脾切除的效果;10例难治性血小板减少者,术后4例出血停止、血小板上升到10万/mm~6以上;9例难治性溶血
This article describes the efficacy of splenectomy in the treatment of idiopathic myeloid metaplasia (AMM). From 1960 to 1977, the author’s unit received a total of 385 AMM cases, including 50 cases of splenectomy, 24 males and 26 females. The average age at surgery is 57 years (36-79 years). Surgery indications are: (1) painful splenomegaly; (2) refractory thrombocytopenia; (3) refractory hemolytic anemia; (4) associated with portal hypertension. Efficacy: 26 cases of painful splenomegaly, after 25 cases of pain disappeared, although the treatment of radiotherapy or alkylating agent can make 66% of patients with spleen shrink, relieve pain, but only ease 3 to 4 months, far less splenectomy Of the results; 10 cases of refractory thrombocytopenia, bleeding stopped after 4 cases, platelets rose to 10 000 / mm ~ 6 above; 9 cases of refractory hemolysis