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Twist属于高度保守的碱性螺旋-环-螺旋(basichelix-loop-helix,bHLH)结构的转录因子家族,在动物和人的胚胎发育、诱导细胞迁移以及组织塑形中起重要作用。Twist基因具有癌基因特征,在多种恶性肿瘤中高表达,不仅参与肿瘤的发生、侵袭和转移,而且与肿瘤细胞产生耐药性密切相关。Twist基因可以通过抗细胞凋亡、干扰抗微管类药物、诱发上皮-间质转型、诱导产生肿瘤干细胞样特性及影响肿瘤微环境等促使肿瘤细胞耐药,因此有望成为逆转肿瘤耐药的新靶点。
Twist belongs to the family of transcription factors that are highly conserved basichelix-loop-helix (bHLH) structures and plays an important role in the development of embryos, cell migration and tissue formation in animals and humans. Twist gene has the features of oncogene, which is highly expressed in a variety of malignant tumors. It is not only involved in tumorigenesis, invasion and metastasis, but also closely related to tumor cell resistance. Twist gene may be a new drug to reverse tumor resistance by anti-apoptosis, interfering with anti-microtubule drugs, inducing epithelial-mesenchymal transition, inducing tumor stem cell-like characteristics and influencing tumor microenvironment and promoting tumor cell resistance Targets.