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Alibert在1806年首先使用“蕈样霉菌病”(MF)的病名.1870年Bazin提出该病的自然进程是从非特异的蕈样前期发展到斑块状病变,最后成为肿瘤.1885年Vidal等认识到存在着暴发型,该型不经过前面两期就出现肿瘤.以后,Besnier等描述了红皮症型.Sezary等于1938年报告了由①红皮症,②具有折叠核的单一核细胞白血病,③在肿大的周围淋巴结中含有同样特点的细胞所组成的三联症.23年后Taswell等在美国文献中正式承认“Sezary”综合征.1968年Lutzner等在Sezary对血液中异常细胞的光学显微镜分析基础上,用电子显微镜证实高度扭曲的细胞核.
Alibert first used the name “Mycosis fungoides” (MF) in 1806. Bazin proposed in 1870 that the natural progression of the disease progressed from a nonspecific mycosis to plaque and eventually a tumor. Vidal et al. Recognized the presence of an outbreak that developed tumors without the previous two phases, and later Besnier et al. Described the erythroderma type. Sezary et al. Reported in 1938 that the disease consisted of ① erythroderma, ② single nucleus with folded nuclei Cell leukemia, and (3) the triad of cells that have the same characteristics in the enlarged lymph nodes around the lymph nodes. Twenty-three years later Taswell et al. Formally recognized the “Sezary syndrome” in the U.S. literature. In 1968 Lutzner et al. Based on optical microscopy analysis of abnormal cells, highly distorted nuclei were confirmed by electron microscopy.