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FoxM1是一种原癌基因。它也是癌发生、发展密切相关的重要的转录因子。Fox M1是Forkhead Box转录因子家族重要成员,定位于染色体12p13.3,特异性表达于增殖期细胞中,在细胞终末分化时消失,是一个典型的与细胞增殖相关的转录因子,在细胞G/S及G/M期转换过程中发挥重要作用。它具有Fox M1A、B和C三种剪接异构体。Fox M1B和C在癌组织中高表达,发挥转录激活、促癌发生和发展的作用,而Fox M1A在癌组织中低表达,发挥转录抑制功能。癌组织中Fox M1B/C的优先选择对于Fox M1发挥促癌作用非常关键。因此对这一现象的成因即Fox M1癌相关选择性剪接机制的研究非常重要。
FoxM1 is a protooncogene. It is also an important transcription factor that is closely related to the occurrence and development of cancer. Fox M1 is an important member of the Forkhead Box family of transcription factors. It locates on chromosome 12p13.3 and is specifically expressed in proliferating cells. It disappears when the cells undergo terminal differentiation. Fox M1 is a typical transcription factor related to cell proliferation. / S and G / M conversion process play an important role. It has three splicing isoforms Fox M1A, B and C. Fox M1B and C are highly expressed in cancerous tissues and play a role in transcriptional activation and tumorigenesis and development. However, Fox M1A is overexpressed in cancerous tissues and plays a transcriptional inhibitory role. The preferential selection of Fox M1B / C in cancerous tissues is crucial for the role of Fox M1 in promoting cancer. Therefore, the cause of this phenomenon is Fox M1 cancer-related alternative splicing mechanism of study is very important.