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目的探讨耐药性部分性发作癫痫采用抗癫痫药物(AEDs)治疗的临床效果及相关影响因素。方法 100例耐药性部分性发作癫痫患者,均继续采取抗癫痫药物治疗,至少观察2年,依据有无达到病情≥1年无发作分为失败组(80例)和缓解组(20例),分析影响治疗的因素。结果本次研究缓解20例,占20%,其中复发13例,保持缓解7例;80例失败,占80%。单因素分析示,治疗失败药物数量≥4种,发作频率在治疗前≥4次/月与耐药性部分性发作癫痫治疗失败相关。结论耐药性部分性发作癫痫采取抗癫痫药物治疗,仍可获得缓解几率,治疗失败药物数量≥4种,治疗前发作频率高,是治疗效果差的临床预测因素。
Objective To investigate the clinical effects and related factors of antiepileptic drugs (AEDs) in the treatment of partial seizure-resistant epilepsy. Methods 100 patients with partial drug-resistant seizures were treated with antiepileptic drugs for at least 2 years. The patients were divided into failure group (n = 80) and remission group (n = 20) , Analyze the factors that affect the treatment. Results In this study, 20 cases were alleviated, accounting for 20%. Among them, 13 cases were relapsed and 7 cases were relieved. 80 cases failed, accounting for 80%. Univariate analysis showed that the number of failed treatment drugs was more than 4 and the frequency of seizures was ≥4 times / month before treatment, which was related to the failure of treatment of partial seizure-resistant epilepsy. Conclusions The drug-resistant partial epilepsy may take some antiepileptic drugs to treat the epilepsy, and the chances of remission may still be obtained. The number of the drugs failing treatment is more than 4, and the high frequency of seizure before treatment is the clinical predictor of poor therapeutic effect.