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目的探讨不同类型单疱病毒性角膜炎患者角膜知觉的变化及其恢复情况。设计病例对照研究。研究对象单疱病毒性角膜炎病人74例78眼,70只对侧健康眼为对照眼。方法利用Cochet-Bonnet角膜感觉仪,对单疱病毒感染的角膜分别测量上方、下方、鼻侧、颞侧角膜缘内1mm处及角膜中央区的角膜知觉,测量患者对侧健眼相应位置的角膜知觉用于对照分析。主要指标角膜知觉敏感度。结果单疱病毒性角膜炎各型均引起角膜知觉下降,其下降程度:浅表型>基质内皮型>瘢痕型,各型角膜炎与健康眼相应位点角膜知觉比较均有显著性差异(P均<0.01)。三种不同类型角膜病变组之间角膜知觉差异无统计学意义。同一类型角膜炎不同位点角膜知觉无显著性差异。结论单疱病毒性角膜炎各型均引起角膜知觉下降,浅表型为著,愈后有恢复趋势。
Objective To investigate the changes and recovery of corneal sensation in patients with different types of herpes simplex keratitis. Design a case-control study. The study included 78 eyes of 74 herpes simplex keratitis patients and 70 contralateral healthy eyes as control eyes. Methods Cochlear corneal sensitometer was used to measure the corneal sensation of the cornea infected by herpes simplex virus at the position 1 mm above and below the corneal limbus, Perception used for the control analysis. Key indicators of corneal sensitivity. Results All types of herpes simplex virus keratitis caused a decrease in corneal sensation. The degree of decrease was: superficial> endothelium> scar type. There was significant difference in corneal sensation between each type of keratitis and healthy eye (P All <0.01). There was no significant difference in corneal perception among the three different types of corneal lesions. The same type of keratitis at different sites corneal awareness no significant difference. Conclusions All types of herpes simplex virus keratitis caused a decrease in corneal sensitivity.