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目的：探讨脉动脉化疗栓塞（TAE）后,反复应用无水乙醇碘油混悬剂经皮肝穿瘤内注射（PEI）治疗巨块型肝细胞癌的疗效。方法：选择原发性巨块型肝细胞癌（HCC）85例。分为联合治疗组（TAE＋PEI，n=43），对照组（TAE，n=42），观察治疗前后两组之间AFP、肿瘤大小、肝功能的变化及总有效率、生存率。结果：联合治疗组的总有效率大88．4％，未出现严重并发症，1年、2年、3年的生存率分别是97．6％，76．8％、52．2％。对照组的总有效率是54．7％，1年、2年、3年生存率分别是77．1％、47．6％、34．1％。两组之间的总有效率和生存率在统计学上差异显著。结论：反复PEI联合TAE治疗巨块型HCC疗效优于单纯TAE。
OBJECTIVE: To investigate the effect of repeated intraperitoneal injection of ethanolic lipiodol suspension (PEI) on massive hepatocellular carcinoma (HCC) after vascular arterial chemoembolization (TAE). METHODS: A total of 85 patients with primary hepatocellular carcinoma (HCC) were selected. They were divided into combination therapy group (TAE+PEI, n=43) and control group (TAE, n=42). Changes of AFP, tumor size, liver function, total effective rate, and survival rate before and after treatment were observed. Results: The combined treatment group had a total effective rate of 88.4%, and no serious complications. The 1-year, 2-year, and 3-year survival rates were 97.6%, 76.8%, and 52.2%, respectively. The total effective rate of the control group was 54.7%, and the 1-year, 2-year, and 3-year survival rates were 77.1%, 47.6%, and 34.1%, respectively. The total effective rate and survival rate between the two groups were statistically significantly different. CONCLUSIONS: Repeated PEI combined with TAE is superior to TAE in the treatment of massive HCC.