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前言肺结核的短程化疗是近十余年来结核化疗的重大进展。短化必须具备两个条件、一是对正在繁殖中的代谢旺盛菌群有强大的杀菌作用;二是对低代谢半休眠菌有强灭菌作用,从而达到两个目的,即痰菌迅速转阴;无复发或复发率很低。由于具有强灭菌作用的利福平(R)问世,和吡嗪酰胺(Z)被证实具有独特的灭菌作用而作为短程疗法第一线药物应用于临床,使肺结核短化成为可能。
Introduction The short-term chemotherapy of tuberculosis is a significant progress of tuberculosis chemotherapy in the past ten years. Shortening must have two conditions, one is vigorous bactericidal effect on the metabolism of exuberant bacteria in the breeding; the second is a strong sterilization of low-metabolizing semi-dormant bacteria, so as to achieve the two purposes, namely sputum bacteria rapidly turn Yin; no recurrence or low recurrence rate. Due to the advent of rifampicin (R), which has a potent bactericidal effect, pyrazinamide (Z) has been shown to have a unique sterilizing effect as a first-line agent for brachytherapy in clinical applications, making it possible to shorten tuberculosis.