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业已证明生物氧化是氧化预处理难浸含金硫化矿的有效工艺。一般地，对硫化物含量高的物料（约30％硫）氧化速率在20％固体浓度时最大。而低品位矿石（1％硫）在55％浓度下亦可成功氧化。这表明在物料的硫化物品位和最佳的作业浓度间有某种联系。据报道，高固体浓度会导致氧化速率降低，停滞期延长，最终氧化度低。本文讨论业已提出的引起这些现象的各种因素。这些因素包括：氧和二氧化碳的可利用量，低细菌──固体化，细菌的机械损伤或抑制，细菌粘附的抑制和细菌浸出产物或其他有害物质如某些浮选药剂的累积。
Biooxidation has proven to be an effective process for the oxidation pretreatment of refractory gold sulphide ores. In general, the oxidation rate of the high sulfide content material (about 30% sulfur) is maximum at 20% solids concentration. Low grade ore (1% sulfur) is also oxidized successfully at 55% concentration. This indicates a link between the sulphide grade of the material and the best working concentration. It has been reported that high solids concentrations lead to reduced oxidation rates, prolonged stationary phase and low final oxidation. This article discusses the various factors that have been proposed to cause these phenomena. These include the availability of oxygen and carbon dioxide, low bacteria - solidification, mechanical damage or inhibition of bacteria, inhibition of bacterial adhesion and the accumulation of bacterial leachate or other harmful substances such as certain flotation agents.