140例直接免疫荧光试验检查结果分析

来源 :皮肤病与性病 | 被引量 : 0次 | 上传用户:landy_st
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狼疮带试验(LBT)是诊断各种自身免疫性疾病的重要手段之一。SLE患者因无皮损,临床上易造成误诊、但通过患者正常皮肤组织的LBT后,结合各种化验结果,能进一步确诊SLE。通过试验发现患者皮肤和肾脏的Ig沉积有高度的相关性,因此,皮肤LBT(+)的患者多有肾脏损害、且皮肤内沉积的Ig数目越多,荧光强度越高、肾病的发生率就越高,病情也较重,预后相对较差。对大疤和疤疹样皮肤病DIF检查结果显示,绝大多数患者在棘细胞间或基底膜处有IC的沉积、总阳性率为82.6%,是早期诊断这类疾病的一种十分可靠的方法。对硬皮病,皮肌炎这类自身免疫性疾病,通过临床表现,结合DIF的检查结果,对诊断有一定的参考价值。关于LBT沉积Ig的类型,如果同时具有IgG、IgA、IgM沉积提示病情较活动,而仅有C3沉积也同样有诊断意义。但仅有IgM沉积时提示病情较轻。在SLE患者,如果同时存在两种以上Ig沉积或与C3并存时,荧光强度在(++)以上常出现多脏器的损害,特别肾脏损害较重。在疤病患者有两种以上Ig同时存在时,强的松的用量常常达到80mg/日以上。因此,根据Ig沉积的类型、数量、强度可作为疾病的治疗及判断预后的重要指标。 Lupus band test (LBT) is an important means of diagnosis of various autoimmune diseases. SLE patients without skin lesions, clinically easy to cause misdiagnosis, but through normal skin tissue of patients with LBT, combined with a variety of laboratory results, to further confirm the SLE. It was found by experiments that there is a high degree of correlation between the Ig deposition in the skin of the patient and the kidneys. Therefore, patients with skin LBT (+) have more kidney damage, and the greater the number of Ig deposited in the skin, the higher the fluorescence intensity. The higher the severity of the disease, the prognosis is relatively poor. The results of DIF examination of large scar and scar-like dermatosis showed that the vast majority of patients had IC deposition at the interspinous membrane or basement membrane, with a total positive rate of 82.6%. It was a reliable early diagnosis of such diseases Methods. On scleroderma, dermatomyosin autoimmune diseases, through clinical manifestations, combined with the DIF test results, the diagnosis of a certain reference value. With regard to the type of IgT deposited by LBT, deposition of IgG, IgA, and IgM at the same time suggests that the disease is more active, and only deposition of C3 is equally diagnostic. However, only IgM deposition suggests a mild condition. In patients with SLE, if there are more than two kinds of Ig deposition or co-exist with the C3, the fluorescence intensity (++) or more often appear multiple organ damage, particularly severe kidney damage. In patients with scarring there are two or more Ig at the same time, the amount of prednisone often up to 80mg / day. Therefore, depending on the type of Ig deposition, quantity, intensity can be used as an important indicator of disease treatment and prognosis.
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