目的　研究颅骨宽度的不同对脑内核团 X坐标值的影响 ,为术中靶点定位提供客观依据。　方法　在西藏高原通过测量 10 4 8例颅骨宽度和 4 2 7例脑内核团的 X坐标值并进行相关分析研究。　结果　颅骨宽度与 Vim靶点 X坐标值 (r= 0 .2 33,P<0 .0 1)和 PVP靶点 X坐标值 (r=0 .2 5 2 ,P<0 .0 0 1)呈显著性正相关 ,随着颅骨宽度的增大 ,Vim和 PVP靶点 X坐标值也随之增大。　结论　颅骨大小的变化可直接影响核团坐标的定位 Objective To study the effect of different widths of skull on the X coordinate value of intracranial nuclei and provide an objective basis for intraoperative targeting. Methods The X-coordinate values ​​of 1048 skull widths and 427 brain nuclei in the Tibetan Plateau were measured and analyzed. Results The skull width was positively correlated with the X coordinate values ​​of Vim target (r = 0.223, P <0.01) and the X coordinate value of PVP target (r = 0.222, P <0.001) Significantly positive correlation, as the skull width increases, Vim and PVP target X coordinate value also increases. Conclusion The change of skull size can directly affect the localization of nucleus coordinates