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目的监测急性有机磷农药中毒(AOPP)患者血清中对氧磷脂酶(PON)活力的变化及其意义。方法检测35例AOPP患者血清中PON的活力水平并与40例健康对照者比较。结果35例AOPP患者入院首次PON活力水平为(55.1±5.3)U/L,明显低于对照组的(144.1±9.2)U/L,差异有统计学意义(P<0.01);35例AOPP患者中,28例随着病情好转血清中PON活力逐渐升高,且入院第3～6天PON活力水平较入院时明显升高,差异有统计学意义(P<0.05),因病情严重而死亡7例患者,入院至死亡PON活力均无明显变化。结论AOPP患者的PON活力降低,随着病情好转血清中PON活力逐渐升高,动态观察PON活力可能对疗效监测和预后判断有一定参考价值。
Objective To monitor the changes of serum paraoxonase (PON) activity in patients with acute organophosphorus pesticide poisoning (AOPP) and its significance. Methods The serum levels of PON in 35 AOPP patients were measured and compared with 40 healthy controls. Results The first PON activity of 35 AOPP patients was (55.1 ± 5.3) U / L, which was significantly lower than that of the control group (144.1 ± 9.2) U / L, with significant difference (P <0.01) , PON activity gradually increased in 28 cases as the condition improved, and the PON activity level on the 3rd to 6th day after admission was significantly higher than that on admission, the difference was statistically significant (P <0.05), due to serious illness and death 7 Cases of patients, admission to death no significant changes in PON activity. Conclusions The PON activity of AOPP patients decreases. As the condition improves, the activity of PON in serum gradually increases. The dynamic observation of PON activity may have some reference value for curative effect monitoring and prognosis judgment.