凋亡亦称细胞自然死亡,是机体清除陈旧细胞,维持正常细胞数量和胚胎发育的重要过程。在形态学上表现为细胞核及胞浆皱缩,凋亡小体形成,最终被吞噬和降解。细胞凋亡受到抑制减少了细胞的生理性死亡,被认为是肿瘤发生的机制之一。最近发现的Bcl-2癌基因可以调节细胞调亡,其产物 Bcl-2癌蛋白广泛存在于神经组织及造血组织等胚胎性组织中, Apoptosis, also known as natural cell death, is an important process of the body to remove old cells, maintain the normal cell number and embryonic development. Morphologically manifested as shrinkage of the nucleus and cytoplasm, formation of apoptotic bodies, and eventually phagocytosis and degradation. Inhibition of apoptosis reduces the cell’s physiological death, is considered one of the mechanisms of tumorigenesis. Recently discovered Bcl-2 oncogene can regulate apoptosis, its product Bcl-2 oncoprotein is widely found in embryonic tissues such as nerve tissue and hematopoietic tissue,