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目的:探讨免疫比浊法和乳胶凝集法检测类风湿因子(RF)结果对类风湿性关节炎(Rheumatoidarthritis,RA)的临床诊断应用价值。方法:用免疫比浊法和乳胶凝集法同时检测阳性组21例类风湿性关节炎患者与正常对照组40例健康体检者的RF,并对结果进行比较分析。结果:免疫比浊法检测阳性组结果阳性率为90.5%,正常对照组阳性率为5%;乳胶凝集法检测阳性组结果阳性率为71.4%,正常对照组未检出阳性标本。两种检测方法结果有显著的相关性,r=0.987,P<0.01。结论:两种检测方法结果相关性良好,免疫比浊法检测RF结果诊断价值较高,敏感性优于乳胶凝集法,免疫比浊法将50IU/ml作为类风湿性关节炎诊断的界限值特异性较高。
Objective: To investigate the clinical value of rheumatoid arthritis (Rheumatoidarthritis, RA) by immunoturbidimetry and latex agglutination in the detection of rheumatoid factor (RF). Methods: The immunoturbidimetric method and latex agglutination method were used to simultaneously detect the RF of 40 healthy subjects in 21 rheumatoid arthritis patients and those in the normal control group. The results were compared and analyzed. Results: The positive rate was 90.5% in the positive group and 5% in the normal control group by immunoturbidimetry. The positive rate of the positive group was 71.4% by latex agglutination test, while the positive group was not detected in the normal control group. There was a significant correlation between the two test results, r = 0.987, P <0.01. Conclusion: The correlation between the two detection methods is good. Immunoturbidimetry is more valuable for the detection of RF, and the sensitivity is better than that of latex agglutination. Immune turbidimetry will be 50IU / ml as the threshold of rheumatoid arthritis diagnosis Sex is higher.