论文部分内容阅读
目的观察静脉滴注丙种球蛋白(IVIG)联合淋巴细胞主动免疫(LIT)治疗复发性流产的效果。方法原因不明性复发性流产患者90例随机均分为两组,分别采用IVIG联合LIT(联合组)和仅接受IVIG(单药组)治疗。检测治疗前后T细胞亚群(CD3~+、CD4~+和CD8~+)、IL-2和IL-10表达水平以及自然杀伤(NK)细胞含量,比较两组患者封闭抗体转阳率及临床妊娠率。结果治疗后,两组CD3~+细胞和CD8~+细胞百分比升高,CD4~+细胞百分比和CD4~+/CD8~+比值均降低,IL-2含量和NK细胞含量均降低,而IL-10含量升高(P<0.05)。联合组以上变化的幅度大于单药组(P<0.05)。治疗后,联合组封闭抗体转阳率为95.56%,高于单药组的82.22%(P<0.05),临床妊娠成功率也高于单药组(86.67%vs.64.44%)(P<0.05)。结论两种治疗方法均能有效改善患者体内免疫状态,提高妊娠成功率;IVIG联合LIT治疗较单独应用IVIG效果更好。
Objective To observe the effect of intravenous immunoglobulin gamma (IVIG) and lymphocyte active immunization (LIT) in the treatment of recurrent spontaneous abortion. Methods Reasons Unexplained recurrent spontaneous abortion 90 patients were randomly divided into two groups were treated with IVIG combined with LIT (combination group) and only received IVIG (single drug group). The levels of CD3 ~ +, CD4 ~ + and CD8 ~ +, IL-2 and IL-10 and the content of natural killer (NK) cells of T cell subsets were detected before and after treatment. Pregnancy rate. Results After treatment, the percentages of CD3 ~ + cells and CD8 ~ + cells in both groups were increased, the percentage of CD4 ~ + cells and the ratio of CD4 ~ + / CD8 ~ + were decreased, while the content of IL- 10 content increased (P <0.05). The changes in the combined group were more than those in the single drug group (P <0.05). After treatment, the positive rate of blocking antibody in the combination group was 95.56%, higher than that in the single drug group (82.22%, P <0.05), and the clinical pregnancy success rate was also higher than that in the single drug group (86.67% vs.64.44%, P <0.05 ). Conclusion Both treatment methods can effectively improve the immune status of patients and improve the success rate of pregnancy. IVIG combined with LIT treatment is better than IVIG alone.