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目的观察毛冬青对SD大鼠慢性心力衰竭(CHF)炎症相关因子及心功能的影响。方法将60只雄性SD大鼠随机分为模型组和假手术组,模型组50只,假手术组10只。结扎腹主动脉建立CHF模型,将模型复制成功的大鼠随机分为4组:毛冬青低剂量组,毛冬青高剂量组,卡托普利组和模型组。分别给予毛冬青、卡托普利或生理盐水灌胃,2周后行经胸超声心动图检测,测定血清白介素-1β(IL-1β)和核因子κB(NF-κB)。结果毛冬青高、低剂量组CHF大鼠血清IL-1β、NF-κB水平明显低于模型组,差异有统计学意义(P<0.05)。心脏彩超显示:毛冬青高、低剂量组大鼠提高射血分数(EF)和短轴缩短率(FS)与模型组比较差异有统计学意义(P<0.05)。结论毛冬青可以改善慢性心力衰竭的炎症状态和心功能。
Objective To observe the effects of Mao Dongqing on the inflammation related factors and cardiac function in chronic heart failure (CHF) rats. Methods Sixty male Sprague-Dawley rats were randomly divided into model group and sham operation group, 50 in model group and 10 in sham operation group. The CHF model was established by ligation of the abdominal aorta. The rats with successful replication were randomly divided into 4 groups: low dose group of Mao Dongqing, high dose group of Mao Dongqing, captopril group and model group. The rats were given Mao Dongqing, captopril or saline respectively. After 2 weeks, the rats were subjected to transthoracic echocardiography to measure the levels of serum IL-1β and NF-κB. Results The levels of serum IL-1β and NF-κB in CHF group were significantly lower than those in model group (P <0.05). Echocardiography showed that there was a significant difference between model group and model group (P <0.05). Conclusion Mao Dongqing can improve the inflammatory state and cardiac function in patients with chronic heart failure.