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目的测定脑脊液(CSF)组织型谷氨酰胺转移酶(tTG),以探讨tTG与帕金森氏病(PD)的关系,进而寻找PD诊断的临床指标。方法选取于门诊或住院治疗的PD患者54例,以及同期住院的非PD患者,腰穿抽取脑脊液,测定tTG浓度。结果PD患者脑脊液tTG浓度为(69.1±3.1)pg/ml,两组比较有统计学意义(P<0.05)。结论测定脑脊液tTG浓度是反映PD患者神经元凋亡的有效手段,用于指导临床治疗。
Objective To determine the expression of tissue transglutaminase (tTG) in cerebrospinal fluid (CSF) in order to explore the relationship between tTG and Parkinson’s disease (PD) and to search for the clinical diagnostic criteria of PD. Methods Totally 54 PD patients were selected outpatient or inpatient hospitalization, and non-PD patients were hospitalized in the same period. Cerebrospinal fluid (CSF) was collected by lumbar puncture and tTG concentration was measured. Results The concentration of tTG in cerebrospinal fluid of PD patients was (69.1 ± 3.1) pg / ml, with statistical significance (P <0.05). Conclusion Determination of cerebrospinal fluid tTG concentration is an effective means to reflect the apoptosis of neurons in PD patients for guiding clinical treatment.