目的　回顾性分析放疗在垂体大腺瘤治疗中的作用和后期反应。　方法　法国波尔多第二大学ＳａｉｎｔＡｎｄｒé医院自１９８１ 年１ 月到１９９１ 年６ 月收治９０ 例垂体大腺瘤，其中８４ 例术后放疗，６ 例单纯放疗。照射剂量为４５～５６Ｇｙ，分次量１－８～２Ｇｙ。　结果　８６ 例肿瘤控制，局控率９５－６％ 。放射后接受甲状腺素、肾上腺皮质激素和性腺激素作为替代治疗的患者分别增加１９％ 、１８％ 和１０ ％ 。４ 例患者因脑血管意外死亡。　结论　对垂体大腺瘤给予４５Ｇｙ 照射疗效好，后期反应少 Objective To retrospectively analyze the role of radiotherapy in the treatment of pituitary macroadenomas and their late response. METHODS: From January 1981 to June 1991, a total of 90 cases of pituitary adenomas were treated at Saint-André Hospital, University of Bordeaux, France. Among them, 84 cases received postoperative radiotherapy and 6 cases received radiotherapy alone. The irradiation dose was 45 to 56 Gy, and the fractional dose was 1-8 to 2 Gy. Results 86 cases of tumor control, the control rate of 95-6%. Patients who received thyroxine, corticosteroids, and gonadal hormones as an alternative therapy after radiation increased by 19%, 18%, and 10%, respectively. Four patients died of cerebrovascular accidents. Conclusion 45Gy irradiation is effective for pituitary adenomas with less late response