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目的探讨异体输血对围手术期胃肠道恶性肿瘤患者血清白介素-2(IL-2)与前列腺素E2(PGE2)的影响。方法采用前瞻性研究方法,将25例胃肠道恶性肿瘤患者,按是否输血分为两组:异体输血组13例和未输血组12例。分别检测两组患者术前第1天、术后1 d、术后7 d的血清IL-2、PGE2含量。结果两组患者根治术前后血清中IL-2和PGE2水平之间的差异均无统计学意义(P>0.05)。两组患者术后1 d、术后7 d的IL-2和PGE2水平也无统计学差异(P>0.05)。结论胃肠道恶性肿瘤根治术前后,病人的免疫状况无明显变化,术后短期内肿瘤复发转移可能性小。另外胃肠道恶性肿瘤患者围手术期异体输血,短期内对患者的免疫功能无明显影响。
Objective To investigate the effect of allogeneic blood transfusion on serum interleukin-2 (IL-2) and prostaglandin E2 (PGE2) in patients with gastrointestinal cancer during perioperative period. Methods A prospective study was conducted to divide 25 patients with gastrointestinal malignancies into two groups according to whether the blood was transfused: 13 in allogeneic transfusion group and 12 in non-transfusion group. The levels of IL-2 and PGE2 in the two groups were detected on the first day, the first day after operation and the seventh day after operation respectively. Results There was no significant difference in serum IL-2 and PGE2 levels between the two groups before and after radical surgery (P> 0.05). There was no significant difference in IL-2 and PGE2 levels between the two groups at postoperative day 1 and postoperative day 7 (P> 0.05). Conclusion Before and after radical operation of gastrointestinal cancer, there is no obvious change in the immune status of the patients, and the possibility of tumor recurrence and metastasis in the short term after operation is small. In addition, patients with gastrointestinal cancer perioperative allogeneic transfusion, short-term immune function in patients with no significant effect.