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初治涂片阳性肺结核病人按不同药物的每日用药剂量随机分配以下治疗,每日服药,2日,利福布丁(Rifabutin.LM427,Ansamycin)600、300、150或75mg,利福平600、300或150mg,异烟肼300mg,或不服药。所谓早期杀菌作用(EBA)是收集2日痰液通过选择性7H-11琼脂培养基上菌落形成单位(CFU)计数来测定结核分支杆菌活菌数的下降。利福布丁的EBA的范围为—0.039(计数增加)到0.049logcfu/ml/日、而EBA从150mg利福平的0.071增加到600mg利福平的0.293log cfu/ml/日,300mg异烟肼为O.43log cfu/ml/日。利福布丁和利福平的EBA差异刚好达到显著性(P=0.05),提示利福布丁对肺空洞内的细胞外杆菌无作用或其作用低于利福平。开始服药后,利福布丁的血浆峰值浓度与其剂量成正比,但比服用同剂量的利福平大约低7倍。利福布丁的EBA比利福平低可能由于低血浆浓度,并不因其在试管内抗结核作用稍高而得到充分补偿。
Newly diagnosed smear-positive pulmonary tuberculosis patients were randomly assigned to receive the following treatments on a daily basis for different doses of the drug: Day 2, Rifabutin.LM427, Ansamycin 600, 300, 150 or 75 mg, Rifampicin 600, 300 or 150 mg, isoniazid 300 mg, or no medication. The so-called early bactericidal effect (EBA) is the collection of sputum on the 2nd through the selective 7H-11 agar medium colony forming units (CFU) count to determine Mycobacterium tuberculosis viable count decreased. The EBA for Rifabutin ranged from -0.039 (count up) to 0.049 log cfu / ml / day while EBA increased from 0.071 for rifampin 150 mg to 0.293 log cfu / ml / day for 600 mg rifampicin, 300 mg isoniazid O.43log cfu / ml / day. The EBA differences between rifabutin and rifampin just reached significance (P = 0.05), suggesting that rifabutin had no effect on the extracellular bacilli in lung cavities or less than rifampicin. After starting the medication, the peak plasma concentration of rifabutin is proportional to its dose, but about seven times lower than taking the same dose of rifampicin. Rifabutin EBA birefacil low may be due to the low plasma concentration, not because of its role in the test tube slightly higher anti-TB and fully compensated.