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目的：观察银杏叶总黄酮（ＴＦＧｂ）抗心肌缺血的作用。方法：采用结扎家兔冠状动脉前降支造成急性心肌梗塞的病理模型，用心电图、血清磷酸肌酸激酶活性和梗死面积评价ＴＦＧｂ对心肌缺血的保护作用。结果：ＴＦＧｂ（１６７ｍｇ·ｋｇ－１·ｄ－１，ｉｐ，连续用药１４ｄ）可明显降低心肌梗塞兔ＥＫＧ中ＳＴ段异常抬高的总幅度以及病理性Ｑ波的出现数；并显著抑制心肌组织磷酸肌酸激酶释放。硝基四氮唑蓝染色显示，预先用ＴＦＧｂ可使心肌梗塞范围明显缩小。结论：ＴＦＧｂ对心肌缺血性损伤具有保护作用
Objective: To observe the anti-ischemic effect of Ginkgo biloba leaf flavonoids (TFGb). METHODS: The pathological model of acute myocardial infarction was induced by ligating the anterior descending coronary artery in rabbits. The protective effect of TFGb on myocardial ischemia was evaluated by electrocardiogram, serum creatine kinase activity, and infarct size. RESULTS: TFGb (167mg·kg-1·d-1, ip, continuous administration for 14 days) significantly reduced the total amplitude of ST-segment abnormalities and the number of pathological Q waves in myocardial infarction EKG rabbits; Myocardial tissue phosphokinase release. Nitroblue tetrazolium staining showed that the use of TFGb can significantly reduce the scope of myocardial infarction. Conclusion: TFGb has a protective effect on myocardial ischemic injury