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44例甲减病人分成三组:重度(9例)、轻度(28例)及亚临床组(7例),分别作STI测定。结果显示:44例甲减病人与对照组比较PEPI显著延长,LVETI显著缩短,PEP/LVET比值显著提高(P均为<0.001),重度组比轻度组STI改变更为显著,而亚临床组与对照组无显著差异;甲减病人T_4与LVETI呈正相关(P<0.01)与PEPI及PEP/LVET呈负相关。12例甲减病人经治疗后随甲状腺功能恢复STI转为正常。以上研究表明STI测定不仅反映甲减患者心功能状况,还能提示其甲状腺激素释放水平高低,并可作为评价甲减患者治疗效果的敏感指标。
44 patients with hypothyroidism were divided into three groups: severe (n = 9), mild (n = 28) and subclinical (n = 7). The results showed that in 44 cases of hypothyroidism, PEPI was significantly prolonged, LVETI was significantly shortened, PEP / LVET ratio was significantly increased (all P <0.001), and STI in severe group was more significant than that in mild group There was no significant difference between the control group and the T_4 of hypothyroidism patients (P <0.01) and PEPI and PEP / LVET. 12 cases of hypothyroidism after treatment with thyroid function returned to normal STI. The above studies show that STI determination not only reflects the cardiac function in patients with hypothyroidism, but also prompts the level of thyroid hormone release, and can be used as a sensitive index to evaluate the therapeutic effect of hypothyroidism.