卵巢过度刺激综合征(ovarian hyperstimula-tion syndrome,OHSS)是促排卵过程中常见的并发症,OHSS的病生理改变为毛细血管通透性的增加,液体从血管内迅速转移到第三间隙,形成胸腔积液、腹水,卵巢囊性增大,甚至血栓、成人呼吸窘迫综合征(ARDS)及肾功能衰竭~[1-3]。现报告1例重度卵巢过度刺激综合征患者,合并宫内早孕双胎,同时阑尾穿孔。卵巢过度刺激综合征患者的腹胀痛症状存在掩盖典型阑尾炎症状的可能,同 Ovarian hyperstimulation syndrome (OHSS) is a common complication in ovulation induction. The physiological change of OHSS is the increase of capillary permeability. The liquid rapidly translocates from the blood vessel to the third gap to form Pleural effusion, ascites, ovarian cysts increased, and even thrombosis, adult respiratory distress syndrome (ARDS) and renal failure ~ [1-3]. Now report a case of severe ovarian hyperstimulation syndrome patients, combined with intrauterine pregnancy twins, while appendix perforation. Symptoms of abdominal pain in patients with ovarian hyperstimulation syndrome may mask the symptoms of typical appendicitis may be the same,