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舒他西林对４种细菌（金葡球菌、肺炎链球菌、大肠杆菌和肺炎克雷伯氏杆菌）共８个菌株分别感染小鼠的体内抗菌作用进行了研究，并以氨苄西林作为对照，以评价舒他西林对小鼠败血症的实验治疗疗效。实验结果显示：对金葡球菌、大肠杆菌和肺炎克雷伯氏杆菌，舒他西林的ＥＤ５０分别是氨苄西林ＥＤ５０的１／２～１／３、１／５～１／６和１／２～１／３，舒他西林的体内抗菌作用优于氨苄西林（Ｐ＜０．０１）。对氨苄西林敏感的肺炎链球菌，两药均显示出强大的抗菌活性，舒他西林的ＥＤ５０为氨苄西林的２～３倍，其抗菌活性逊于氨苄西林（Ｐ＜０．０１）。
The antibacterial activity of the four strains of bacteria (Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli and Klebsiella pneumoniae) infected by 8 strains of isolates from mice was studied by sultamicillin. Ampicillin was used as control To evaluate the efficacy of sultamicillin in the experimental treatment of sepsis in mice. The results showed that the ED50 of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae, and sultamicillin were 1/2 ~ 1/3, 1/5 ~ 1/6 and 1/2 ~ 1/3, the antibacterial effect of sultamicillin in vivo is better than that of ampicillin (P <0.01). Ampicillin-sensitive Streptococcus pneumoniae both showed strong antibacterial activity. The ED50 of sultamicillin was 2 to 3 times higher than that of ampicillin, and its antibacterial activity was inferior to that of ampicillin (P <0.01).