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【据《Proc Natl Acad Sci U S A》2015年5月报道】题:细胞内凋亡蛋白拮抗剂抑制HBV的清除(作者Ebert G等)感染HBV后可以引发一系列的症状,包括从免疫介导的调节作用到疾病的进展,肝硬化和肝癌,导致这些结果的宿主分子途径仍需要研究。来自墨尔本大学的Ebert G等通过具有免疫能力的慢性HBV感染小鼠来研究影响HBV感染的宿主细胞与分子因素。结果发现,在HBV感染过程中细胞内凋亡蛋白抑制剂(c IAPs)可以减弱肿瘤坏死因子(TNF)信号,他们可以抑制感染后的肝细胞死亡从而导致病毒的持续感染。与野生型小鼠相比,肝脏特异的c IAP1和总
According to “Proc Natl Acad Sci USA” May 2015 Report Title: Inhibition of HBV clearance by intracellular apoptotic protein antagonists (by Ebert G et al.) Infection with HBV can trigger a range of symptoms, including immune-mediated Regulatory effects on disease progression, cirrhosis and liver cancer, host molecule pathways that lead to these results still need to be studied. Ebert G from the University of Melbourne et al. Studied host cells and molecular factors that affect HBV infection by immunizing mice with chronic HBV infection. The results showed that intracellular inhibitors of apoptosis proteins (c IAPs) attenuate tumor necrosis factor (TNF) signaling during HBV infection and they can inhibit the death of infected hepatocytes leading to a sustained infection of the virus. Compared with wild-type mice, liver-specific c IAP1 and total